PTPRR Antibody - #DF12713
| Product: | PTPRR Antibody |
| Catalog: | DF12713 |
| Description: | Rabbit polyclonal antibody to PTPRR |
| Application: | WB |
| Reactivity: | Human, Mouse, Rat |
| Prediction: | Pig, Zebrafish, Bovine, Horse, Sheep, Rabbit, Dog, Xenopus |
| Mol.Wt.: | 47 kDa; 74kD(Calculated). |
| Uniprot: | Q15256 |
| RRID: | AB_2845674 |
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Protocols
Product Info
*The optimal dilutions should be determined by the end user.
*Tips:
WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.
Cite Format: Affinity Biosciences Cat# DF12713, RRID:AB_2845674.
Fold/Unfold
Ch-1PTPase; Ch1 PTPase; DKFZp781C1038; EC PTP; ECPTP; FLJ34328; MGC131968; MGC148170; NC PTPCOM1; NC-PTPCOM1; Protein tyrosine phosphatase Cr1PTPase precursor; Protein tyrosine phosphatase NC PTPCOM1; Protein tyrosine phosphatase PCPTP1; Protein tyrosine phosphatase receptor type R; Protein-tyrosine phosphatase PCPTP1; PTP SL; PTPBR7; PTPRQ; PTPRR; PTPRR_HUMAN; PTPSL; R-PTP-R; Receptor type tyrosine protein phosphatase R; Receptor-type tyrosine-protein phosphatase R;
Immunogens
Expressed in brain, placenta, small intestine, stomach, uterus and weakly in the prostate. Isoform alpha has been observed only in the brain. Isoform gamma is expressed in brain, placenta and uterus. Isoform delta is expressed in brain, kidney, placenta, prostate, small intestine and uterus.
- Q15256 PTPRR_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MRRAVCFPALCLLLNLHAAGCFSGNNDHFLAINQKKSGKPVFIYKHSQDIEKSLDIAPQKIYRHSYHSSSEAQVSKRHQIVNSAFPRPAYDPSLNLLAMDGQDLEVENLPIPAANVIVVTLQMDVNKLNITLLRIFRQGVAAALGLLPQQVHINRLIGKKNSIELFVSPINRKTGISDALPSEEVLRSLNINVLHQSLSQFGITEVSPEKNVLQGQHEADKIWSKEGFYAVVIFLSIFVIIVTCLMILYRLKERFQLSLRQDKEKNQEIHLSPITLQPALSEAKTVHSMVQPEQAPKVLNVVVDPQGRGAPEIKATTATSVCPSPFKMKPIGLQERRGSNVSLTLDMSSLGNIEPFVSIPTPREKVAMEYLQSASRILTRSQLRDVVASSHLLQSEFMEIPMNFVDPKEIDIPRHGTKNRYKTILPNPLSRVCLRPKNVTDSLSTYINANYIRGYSGKEKAFIATQGPMINTVDDFWQMVWQEDSPVIVMITKLKEKNEKCVLYWPEKRGIYGKVEVLVISVNECDNYTIRNLVLKQGSHTQHVKHYWYTSWPDHKTPDSAQPLLQLMLDVEEDRLASQGRGPVVVHCSAGIGRTGCFIATSIGCQQLKEEGVVDALSIVCQLRMDRGGMVQTSEQYEFVHHALCLYESRLSAETVQ
Predictions
Score>80(red) has high confidence and is suggested to be used for WB detection. *The prediction model is mainly based on the alignment of immunogen sequences, the results are for reference only, not as the basis of quality assurance.
High(score>80) Medium(80>score>50) Low(score<50) No confidence
PTMs - Q15256 As Substrate
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| Y44 | Phosphorylation | Uniprot | |
| Y62 | Phosphorylation | Uniprot | |
| S272 | Phosphorylation | Uniprot | |
| S324 | Phosphorylation | Uniprot | |
| S342 | Phosphorylation | Uniprot | |
| S358 | Phosphorylation | Uniprot | |
| T361 | Phosphorylation | Uniprot | |
| Y370 | Phosphorylation | Uniprot | |
| S430 | Phosphorylation | Uniprot | |
| T440 | Phosphorylation | Uniprot | |
| S456 | Phosphorylation | Uniprot | |
| Y504 | Phosphorylation | Uniprot | |
| Y547 | Phosphorylation | Uniprot |
Research Backgrounds
Sequesters mitogen-activated protein kinases (MAPKs) such as MAPK1, MAPK3 and MAPK14 in the cytoplasm in an inactive form. The MAPKs bind to a dephosphorylated kinase interacting motif, phosphorylation of which by the protein kinase A complex releases the MAPKs for activation and translocation into the nucleus (By similarity).
Cell membrane>Single-pass type I membrane protein.
Cytoplasm>Perinuclear region.
Note: Locates to the perinuclear areas within the cytoplasm.
Cytoplasm>Perinuclear region.
Note: Locates to the perinuclear areas within the cytoplasm.
Expressed in brain, placenta, small intestine, stomach, uterus and weakly in the prostate. Isoform alpha has been observed only in the brain. Isoform gamma is expressed in brain, placenta and uterus. Isoform delta is expressed in brain, kidney, placenta, prostate, small intestine and uterus.
Interacts with MAPKs.
Belongs to the protein-tyrosine phosphatase family. Receptor class 7 subfamily.
Research Fields
· Environmental Information Processing > Signal transduction > MAPK signaling pathway. (View pathway)
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