DUSP7/PYST2 Antibody - #DF12964
| Product: | DUSP7/PYST2 Antibody |
| Catalog: | DF12964 |
| Description: | Rabbit polyclonal antibody to DUSP7/PYST2 |
| Application: | WB |
| Reactivity: | Human, Mouse, Rat |
| Prediction: | Pig, Zebrafish, Bovine, Horse, Sheep, Rabbit, Dog, Chicken, Xenopus |
| Mol.Wt.: | 45 kDa; 45kD(Calculated). |
| Uniprot: | Q16829 |
| RRID: | AB_2845925 |
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Protocols
Product Info
*The optimal dilutions should be determined by the end user.
*Tips:
WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.
Cite Format: Affinity Biosciences Cat# DF12964, RRID:AB_2845925.
Fold/Unfold
Dual specificity phosphatase 7; Dual specificity protein phosphatase 7; Dual specificity protein phosphatase PYST2; DUS7_HUMAN; Dusp7; Jnk Stimulatory Phosphatase 1; JSP1; MAP kinase phosphatase X; MKPX; PYST2;
Immunogens
Strongly expressed in liver (PubMed:8670865). Expressed at significantly higher levels in malignant hematopoietic cells than in corresponding non-malignant cells (PubMed:14576828).
- Q16829 DUS7_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MKNQLRGPPARAHMSTSGAAAAGGTRAGSEPGAGSGSGAGTGAGAATGAGAMPCKSAEWLQEELEARGGASLLLLDCRPHELFESSHIETAINLAIPGLMLRRLRKGNLPIRSIIPNHADKERFATRCKAATVLLYDEATAEWQPEPGAPASVLGLLLQKLRDDGCQAYYLQGGFNKFQTEYSEHCETNVDSSSSPSSSPPTSVLGLGGLRISSDCSDGESDRELPSSATESDGSPVPSSQPAFPVQILPYLYLGCAKDSTNLDVLGKYGIKYILNVTPNLPNAFEHGGEFTYKQIPISDHWSQNLSQFFPEAISFIDEARSKKCGVLVHCLAGISRSVTVTVAYLMQKMNLSLNDAYDFVKRKKSNISPNFNFMGQLLDFERTLGLSSPCDNHASSEQLYFSTPTNHNLFPLNTLEST
Predictions
Score>80(red) has high confidence and is suggested to be used for WB detection. *The prediction model is mainly based on the alignment of immunogen sequences, the results are for reference only, not as the basis of quality assurance.
High(score>80) Medium(80>score>50) Low(score<50) No confidence
PTMs - Q16829 As Substrate
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| K2 | Methylation | Uniprot | |
| K106 | Ubiquitination | Uniprot | |
| K121 | Ubiquitination | Uniprot | |
| T132 | Phosphorylation | Uniprot | |
| Y136 | Phosphorylation | Uniprot | |
| T140 | Phosphorylation | Uniprot | |
| S152 | Phosphorylation | Uniprot | |
| Y169 | Phosphorylation | Uniprot | |
| Y170 | Phosphorylation | Uniprot | |
| K268 | Ubiquitination | Uniprot | |
| S315 | Phosphorylation | Uniprot | |
| K362 | Ubiquitination | Uniprot | |
| K365 | Ubiquitination | Uniprot | |
| S366 | Phosphorylation | Uniprot | |
| S369 | Phosphorylation | Uniprot |
Research Backgrounds
Dual specificity protein phosphatase. Shows high activity towards MAPK1/ERK2. Also has lower activity towards MAPK14 and MAPK8. In arrested oocytes, plays a role in meiotic resumption (By similarity). Promotes nuclear envelope breakdown and activation of the CDK1/Cyclin-B complex in oocytes, probably by dephosphorylating and inactivating the conventional protein kinase C (cPKC) isozyme PRKCB (By similarity). May also inactivate PRKCA and/or PRKCG (By similarity). Also important in oocytes for normal chromosome alignment on the metaphase plate and progression to anaphase, where it might regulate activity of the spindle-assembly checkpoint (SAC) complex (By similarity).
Cytoplasm.
Strongly expressed in liver. Expressed at significantly higher levels in malignant hematopoietic cells than in corresponding non-malignant cells.
Interacts with MAPK1/ERK2; the interaction enhances DUSP7 phosphatase activity.
Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.
Research Fields
· Environmental Information Processing > Signal transduction > MAPK signaling pathway. (View pathway)
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