Product: CD64 Antibody
Catalog: DF13670
Description: Rabbit polyclonal antibody to CD64
Application: WB IF/ICC
Reactivity: Human, Rat
Mol.Wt.: 42kDa; 43kD(Calculated).
Uniprot: P12314
RRID: AB_2846689

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 100ul $280 In stock
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Product Info

Source:
Rabbit
Application:
IF/ICC 1:100-1:500, WB 1:500-1:2000
*The optimal dilutions should be determined by the end user.
*Tips:

WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.

Reactivity:
Human,Rat
Clonality:
Polyclonal
Specificity:
CD64 Antibody detects endogenous levels of total CD64.
RRID:
AB_2846689
Cite Format: Affinity Biosciences Cat# DF13670, RRID:AB_2846689.
Conjugate:
Unconjugated.
Purification:
The antiserum was purified by peptide affinity chromatography using SulfoLink™ Coupling Resin (Thermo Fisher Scientific).
Storage:
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at -20 °C. Stable for 12 months from date of receipt.
Alias:

Fold/Unfold

CD64; CD64A; Fc fragment of IgG high affinity Ia receptor (CD64); Fc fragment of IgG, high affinity Ia, receptor for; Fc gamma receptor; Fc gamma receptor I A1; Fc gamma RI; Fc gamma RIA; Fc-gamma RI; Fc-gamma RIA; FCG1; FcgammaRIa; FCGR1; FCGR1_HUMAN; FCGR1A; FcRI; FLJ18345; High affinity immunoglobulin gamma Fc receptor I; IGFR1; IgG Fc receptor I; Immunoglobulin G Fc receptor I; OTTHUMP00000013913;

Immunogens

Immunogen:
Uniprot:
Gene(ID):
Expression:
P12314 FCGR1_HUMAN:

Monocyte/macrophage specific.

Sequence:
MWFLTTLLLWVPVDGQVDTTKAVITLQPPWVSVFQEETVTLHCEVLHLPGSSSTQWFLNGTATQTSTPSYRITSASVNDSGEYRCQRGLSGRSDPIQLEIHRGWLLLQVSSRVFTEGEPLALRCHAWKDKLVYNVLYYRNGKAFKFFHWNSNLTILKTNISHNGTYHCSGMGKHRYTSAGISVTVKELFPAPVLNASVTSPLLEGNLVTLSCETKLLLQRPGLQLYFSFYMGSKTLRGRNTSSEYQILTARREDSGLYWCEAATEDGNVLKRSPELELQVLGLQLPTPVWFHVLFYLAVGIMFLVNTVLWVTIRKELKRKKKWDLEISLDSGHEKKVISSLQEDRHLEEELKCQEQKEEQLQEGVHRKEPQGAT

PTMs - P12314 As Substrate

Site PTM Type Enzyme
N59 N-Glycosylation
T73 Phosphorylation
S74 Phosphorylation
S76 Phosphorylation
N78 N-Glycosylation
Y133 Phosphorylation
Y137 Phosphorylation
Y138 Phosphorylation
N152 N-Glycosylation
N159 N-Glycosylation
N163 N-Glycosylation
N195 N-Glycosylation
S328 Phosphorylation
S340 Phosphorylation

Research Backgrounds

Function:

High affinity receptor for the Fc region of immunoglobulins gamma. Functions in both innate and adaptive immune responses.

PTMs:

Phosphorylated on serine residues.

Subcellular Location:

Cell membrane>Single-pass type I membrane protein.
Note: Stabilized at the cell membrane through interaction with FCER1G.

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionSubcellular location
Tissue Specificity:

Monocyte/macrophage specific.

Subunit Structure:

Interacts with FCERG1; forms a functional signaling complex. Interacts with FLNA; prevents FCGR1A degradation. Interacts with EPB41L2, LAT and PPL. Interacts with HCK and LYN.

Family&Domains:

Belongs to the immunoglobulin superfamily. FCGR1 family.

Research Fields

· Cellular Processes > Transport and catabolism > Phagosome.   (View pathway)

· Human Diseases > Infectious diseases: Parasitic > Leishmaniasis.

· Human Diseases > Infectious diseases: Bacterial > Staphylococcus aureus infection.

· Human Diseases > Infectious diseases: Bacterial > Tuberculosis.

· Human Diseases > Cancers: Overview > Transcriptional misregulation in cancer.

· Human Diseases > Cancers: Specific types > Acute myeloid leukemia.   (View pathway)

· Human Diseases > Immune diseases > Systemic lupus erythematosus.

· Organismal Systems > Development > Osteoclast differentiation.   (View pathway)

· Organismal Systems > Immune system > Hematopoietic cell lineage.   (View pathway)

· Organismal Systems > Immune system > Fc gamma R-mediated phagocytosis.   (View pathway)

Restrictive clause

 

Affinity Biosciences tests all products strictly. Citations are provided as a resource for additional applications that have not been validated by Affinity Biosciences. Please choose the appropriate format for each application and consult Materials and Methods sections for additional details about the use of any product in these publications.

For Research Use Only.
Not for use in diagnostic or therapeutic procedures. Not for resale. Not for distribution without written consent. Affinity Biosciences will not be held responsible for patent infringement or other violations that may occur with the use of our products. Affinity Biosciences, Affinity Biosciences Logo and all other trademarks are the property of Affinity Biosciences LTD.