CRH Recombinant Rabbit mAb - #BF3584

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Product: CRH Recombinant Rabbit mAb
Catalog: BF3584
Description: Rabbit monoclonal antibody to CRH
Application: WB
Reactivity: Human, Mouse, Rat
Mol.Wt.: 21 kDa(Observed); 21kD(Calculated).
Uniprot: P06850

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 100ul $280 In stock

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Protocols
WB Handbook
IHC Protocol
IF/ICC Protocol

Product Info

Source:
Rabbit IgG
Application:
WB 1:1000
*The optimal dilutions should be determined by the end user. For optimal experimental results, antibody reuse is not recommended.
*Tips:

WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.

Reactivity:
Human,Mouse,Rat
Clonality:
Monoclonal [ReFirm23031]
Specificity:
CRH Recombinant Rabbit mAb detects endogenous levels of CRH.
Conjugate:
Unconjugated.
Purification:
Affinity-chromatography.
Storage:
Rabbit IgG in Tris-Glycine (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at -20 °C. Stable for 12 months from date of receipt.
Alias:

Fold/Unfold

Corticoliberin; Corticotropin releasing factor; Corticotropin releasing hormone; CRF; Crh; CRH1;

Immunogens

Immunogen:

A synthetic peptide from human CRH

Uniprot:

P06850(CRF_HUMAN) >>Visit HPA database.

Gene(ID):
CRH(1392)
Expression:
P06850 CRF_HUMAN:

Produced by the hypothalamus and placenta.

Description:
This gene encodes a member of the corticotropin-releasing factor family. The encoded preproprotein is proteolytically processed to generate the mature neuropeptide hormone. In response to stress,this hormone is secreted by the paraventricular nucleus (PVN) of the hypothalamus,binds to corticotropin releasing hormone receptors and stimulates the release of adrenocorticotropic hormone from the pituitary gland. Marked reduction in this protein has been observed in association with Alzheimer's disease. Autosomal recessive hypothalamic corticotropin deficiency has multiple and potentially fatal metabolic consequences including hypoglycemia and hepatitis. In addition to production in the hypothalamus,this protein is also synthesized in peripheral tissues,such as T lymphocytes,and is highly expressed in the placenta. In the placenta it is a marker that determines the length of gestation and the timing of parturition and delivery. A rapid increase in circulating levels of the hormone occurs at the onset of parturition,suggesting that,in addition to its metabolic functions,this protein may act as a trigger for parturition.
Sequence:
MRLPLLVSAGVLLVALLPCPPCRALLSRGPVPGARQAPQHPQPLDFFQPPPQSEQPQQPQARPVLLRMGEEYFLRLGNLNKSPAAPLSPASSLLAGGSGSRPSPEQATANFFRVLLQQLLLPRRSLDSPAALAERGARNALGGHQEAPERERRSEEPPISLDLTFHLLREVLEMARAEQLAQQAHSNRKLMEIIGK

Research Backgrounds

Function:

Hormone regulating the release of corticotropin from pituitary gland (By similarity). Induces NLRP6 in intestinal epithelial cells, hence may influence gut microbiota profile (By similarity).

Subcellular Location:

Secreted.

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionSubcellular location
Tissue Specificity:

Produced by the hypothalamus and placenta.

Family&Domains:

Belongs to the sauvagine/corticotropin-releasing factor/urotensin I family.

Research Fields

· Human Diseases > Substance dependence > Alcoholism.

· Organismal Systems > Nervous system > Long-term depression.

Restrictive clause

 

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For Research Use Only.
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