DEGS1 Recombinant Rabbit mAb - #BF4481

Copy Info
Product: DEGS1 Recombinant Rabbit mAb
Catalog: BF4481
Description: Rabbit monoclonal antibody to DEGS1
Application: WB
Reactivity: Human
Mol.Wt.: 38 kDa(Observed); 38kD(Calculated).
Uniprot: O15121

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MSDS
Data Sheet
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Protocols
WB Handbook
IHC Protocol
IF/ICC Protocol

Product Info

Source:
Rabbit IgG
Application:
WB 1:1000-1:5000
*The optimal dilutions should be determined by the end user. For optimal experimental results, antibody reuse is not recommended.
*Tips:

WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.

Reactivity:
Human
Clonality:
Monoclonal [ReFirm23931]
Specificity:
DEGS1 Recombinant Rabbit mAb detects endogenous levels of DEGS1.
Conjugate:
Unconjugated.
Purification:
Affinity-chromatography.
Storage:
Rabbit IgG in Tris-Glycine (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at -20 °C. Stable for 12 months from date of receipt.
Alias:

Fold/Unfold

Degenerative spermatocyte homolog 1; Degenerative spermatocyte homolog 1 lipid desaturase; Degenerative spermatocyte homolog lipid desaturase; DEGS 1; DEGS; Delta 4 desaturase sphingolipid 1; Des 1; DES1; Dihydroceramide desaturase; FADS7; Membrane fatty acid (lipid) desaturase; Membrane lipid desaturase; MGC5079; MIG15; Migration inducing gene 15 protein; MLD; Sphingolipid delta 4 desaturase; Sphingolipid delta(4) desaturase DES1;

Immunogens

Immunogen:

A synthetic peptide from human DEGS1

Uniprot:

O15121(DEGS1_HUMAN) >>Visit HPA database.

Gene(ID):
DEGS1(8560)
Expression:
O15121 DEGS1_HUMAN:

Ubiquitous.

Description:
This gene encodes a member of the membrane fatty acid desaturase family which is responsible for inserting double bonds into specific positions in fatty acids. This protein contains three His-containing consensus motifs that are characteristic of a group of membrane fatty acid desaturases. It is predicted to be a multiple membrane-spanning protein localized to the endoplasmic reticulum. Overexpression of this gene inhibited biosynthesis of the EGF receptor,suggesting a possible role of a fatty acid desaturase in regulating biosynthetic processing of the EGF receptor.
Sequence:
MGSRVSREDFEWVYTDQPHADRRREILAKYPEIKSLMKPDPNLIWIIIMMVLTQLGAFYIVKDLDWKWVIFGAYAFGSCINHSMTLAIHEIAHNAAFGNCKAMWNRWFGMFANLPIGIPYSISFKRYHMDHHRYLGADGVDVDIPTDFEGWFFCTAFRKFIWVILQPLFYAFRPLFINPKPITYLEVINTVAQVTFDILIYYFLGIKSLVYMLAASLLGLGLHPISGHFIAEHYMFLKGHETYSYYGPLNLLTFNVGYHNEHHDFPNIPGKSLPLVRKIAAEYYDNLPHYNSWIKVLYDFVMDDTISPYSRMKRHQKGEMVLE

Research Backgrounds

Function:

Has sphingolipid-delta-4-desaturase activity. Converts D-erythro-sphinganine to D-erythro-sphingosine (E-sphing-4-enine).

PTMs:

Myristoylation can target the enzyme to the mitochondria leading to an increase in ceramide levels.

Subcellular Location:

Mitochondrion membrane. Endoplasmic reticulum membrane>Multi-pass membrane protein.

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionSubcellular location
Tissue Specificity:

Ubiquitous.

Family&Domains:

Belongs to the fatty acid desaturase type 1 family. DEGS subfamily.

Research Fields

· Environmental Information Processing > Signal transduction > Sphingolipid signaling pathway.   (View pathway)

· Metabolism > Lipid metabolism > Sphingolipid metabolism.

· Metabolism > Global and overview maps > Metabolic pathways.

Restrictive clause

 

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For Research Use Only.
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