MAP4K3 Antibody - #DF3342
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Product Info
*The optimal dilutions should be determined by the end user.
*Tips:
WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.
Cite Format: Affinity Biosciences Cat# DF3342, RRID:AB_2835709.
Fold/Unfold
Germinal center kinase like kinase; Germinal center kinase-related protein kinase; GLK; MAPK/ERK kinase kinase kinase 3; MAPKKKK3; MEK kinase kinase 3; MEKKK 3; MEKKK3; mitogen-activated protein kinase kinase kinase kinase 3; RAB8IPL1;
Immunogens
Ubiquitously expressed in all tissues examined, with high levels in heart, brain, placenta, skeletal muscle, kidney and pancreas and lower levels in lung and liver.
- Q8IVH8 M4K3_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MNPGFDLSRRNPQEDFELIQRIGSGTYGDVYKARNVNTGELAAIKVIKLEPGEDFAVVQQEIIMMKDCKHPNIVAYFGSYLRRDKLWICMEFCGGGSLQDIYHVTGPLSELQIAYVSRETLQGLYYLHSKGKMHRDIKGANILLTDNGHVKLADFGVSAQITATIAKRKSFIGTPYWMAPEVAAVERKGGYNQLCDLWAVGITAIELAELQPPMFDLHPMRALFLMTKSNFQPPKLKDKMKWSNSFHHFVKMALTKNPKKRPTAEKLLQHPFVTQHLTRSLAIELLDKVNNPDHSTYHDFDDDDPEPLVAVPHRIHSTSRNVREEKTRSEITFGQVKFDPPLRKETEPHHELPDSDGFLDSSEEIYYTARSNLDLQLEYGQGHQGGYFLGANKSLLKSVEEELHQRGHVAHLEDDEGDDDESKHSTLKAKIPPPLPPKPKSIFIPQEMHSTEDENQGTIKRCPMSGSPAKPSQVPPRPPPPRLPPHKPVALGNGMSSFQLNGERDGSLCQQQNEHRGTNLSRKEKKDVPKPISNGLPPTPKVHMGACFSKVFNGCPLKIHCASSWINPDTRDQYLIFGAEEGIYTLNLNELHETSMEQLFPRRCTWLYVMNNCLLSISGKASQLYSHNLPGLFDYARQMQKLPVAIPAHKLPDRILPRKFSVSAKIPETKWCQKCCVVRNPYTGHKYLCGALQTSIVLLEWVEPMQKFMLIKHIDFPIPCPLRMFEMLVVPEQEYPLVCVGVSRGRDFNQVVRFETVNPNSTSSWFTESDTPQTNVTHVTQLERDTILVCLDCCIKIVNLQGRLKSSRKLSSELTFDFQIESIVCLQDSVLAFWKHGMQGRSFRSNEVTQEISDSTRIFRLLGSDRVVVLESRPTDNPTANSNLYILAGHENSY
Predictions
Score>80(red) has high confidence and is suggested to be used for WB detection. *The prediction model is mainly based on the alignment of immunogen sequences, the results are for reference only, not as the basis of quality assurance.
High(score>80) Medium(80>score>50) Low(score<50) No confidence
PTMs - Q8IVH8 As Substrate
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| M1 | Acetylation | Uniprot | |
| S24 | Phosphorylation | Uniprot | |
| T26 | Phosphorylation | Uniprot | |
| Y27 | Phosphorylation | Uniprot | |
| Y31 | Phosphorylation | Uniprot | |
| K32 | Ubiquitination | Uniprot | |
| T145 | Phosphorylation | Uniprot | |
| S158 | Phosphorylation | Uniprot | |
| T164 | Phosphorylation | Uniprot | |
| K167 | Ubiquitination | Uniprot | |
| S170 | Phosphorylation | Q8IVH8 (MAP4K3) | Uniprot |
| S280 | Phosphorylation | Uniprot | |
| T327 | Phosphorylation | Uniprot | |
| S329 | Phosphorylation | Uniprot | |
| Y366 | Phosphorylation | Uniprot | |
| Y367 | Phosphorylation | Uniprot | |
| Y379 | Phosphorylation | Uniprot | |
| Y387 | Phosphorylation | Uniprot | |
| K397 | Ubiquitination | Uniprot | |
| S398 | Phosphorylation | Uniprot | |
| S422 | Phosphorylation | Uniprot | |
| S467 | Phosphorylation | Uniprot | |
| S507 | Phosphorylation | Uniprot | |
| K530 | Acetylation | Uniprot | |
| S533 | Phosphorylation | Uniprot | |
| T539 | Phosphorylation | Uniprot | |
| K541 | Acetylation | Uniprot | |
| S616 | Phosphorylation | Uniprot | |
| S618 | Phosphorylation | Uniprot | |
| S661 | Phosphorylation | Uniprot | |
| Y735 | Phosphorylation | Uniprot | |
| S743 | Phosphorylation | Uniprot | |
| S893 | Phosphorylation | Uniprot |
PTMs - Q8IVH8 As Enzyme
Research Backgrounds
May play a role in the response to environmental stress. Appears to act upstream of the JUN N-terminal pathway.
Ubiquitously expressed in all tissues examined, with high levels in heart, brain, placenta, skeletal muscle, kidney and pancreas and lower levels in lung and liver.
Interacts with SH3GL2. Interaction appears to regulate MAP4K3-mediated JNK activation (By similarity).
Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.
Research Fields
· Environmental Information Processing > Signal transduction > MAPK signaling pathway. (View pathway)
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