SMO Antibody - #DF5152
|Application:||WB, IHC, IF/ICC|
|Reactivity:||Human, Mouse, Rat|
|Prediction:||Pig, Bovine, Horse, Rabbit, Chicken|
|Mol.Wt.:||86 KD; 86kD(Calculated).|
*The optimal dilutions should be determined by the end user.
WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.
Cite Format: Affinity Biosciences Cat# DF5152, RRID:AB_2837342.
Frizzled family member 11; FZD11; Gx; Gx protein; Protein Gx; SMO; SMO_HUMAN; SMOH; Smoothened frizzled family receptor; Smoothened homolog (Drosophila); Smoothened homolog; Smoothened homolog precursor (SMO) (Gx protein); Smoothened seven transmembrane spanning receptor;
- Q99835 SMO_HUMAN:
- Protein BLAST With
Score>80(red) has high confidence and is suggested to be used for WB detection. *The prediction model is mainly based on the alignment of immunogen sequences, the results are for reference only, not as the basis of quality assurance.
High(score>80) Medium(80>score>50) Low(score<50) No confidence
PTMs - Q99835 As Substrate
G protein-coupled receptor that probably associates with the patched protein (PTCH) to transduce the hedgehog's proteins signal. Binding of sonic hedgehog (SHH) to its receptor patched is thought to prevent normal inhibition by patched of smoothened (SMO). Required for the accumulation of KIF7, GLI2 and GLI3 in the cilia. Interacts with DLG5 at the ciliary base to induce the accumulation of KIF7 and GLI2 at the ciliary tip for GLI2 activation (By similarity).
Membrane>Multi-pass membrane protein. Cell projection>Cilium.
Homodimer. Interacts with ARRB2 (By similarity). Interacts with KIF7. Interacts with BBS5 and BBS7; the interactions are indicative for the association of SMO with the BBsome complex to facilitate ciliary localization of SMO. Interacts with DLG5 and SDCBP (By similarity). Interacts with GAS8/DRC4.
Belongs to the G-protein coupled receptor Fz/Smo family.
· Environmental Information Processing > Signal transduction > Hedgehog signaling pathway. (View pathway)
· Human Diseases > Cancers: Overview > Pathways in cancer. (View pathway)
· Human Diseases > Cancers: Overview > Proteoglycans in cancer.
· Human Diseases > Cancers: Specific types > Basal cell carcinoma. (View pathway)
· Organismal Systems > Development > Axon guidance. (View pathway)
Application: WB Species: mouse Sample: BGC823MCAs and SGC7901MCAs
Application: WB Species: human Sample: HIBECs
Application: WB Species: Mice Sample: HEI-OC1 cells
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