LASS4 Antibody - #AF0499
*The optimal dilutions should be determined by the end user.
WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.
Cite Format: Affinity Biosciences Cat# AF0499, RRID:AB_2834220.
ceramide synthase 4; CerS4; FLJ12089; LAG1 homolog ceramide synthase 4; LAG1 longevity assurance homolog 4; LAG1, S. cerevisiae, homolog of, 4; LASS 4; LASS4; LASS4 LAG1 homolog ceramide synthase 4; LASS4_HUMAN; TRAM homolog 1; Trh 1; Trh1;
PTMs - Q9HA82 As Substrate
Ceramide synthase that catalyzes formation of ceramide from sphinganine and acyl-CoA substrates, with high selectivity toward long and very-long chains (C18:0-C22:0) as acyl donor.
Phosphorylated at the C-terminus by CK2.
Endoplasmic reticulum membrane>Multi-pass membrane protein.
The last loop motif confers selectivity toward stearoyl-CoA (octadecanoyl-CoA; C18:0-CoA) to behenoyl-CoA (docosanoyl-CoA; C22:0-CoA) as acyl donors.
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