Caveolin 3 Recombinant Rabbit mAb - #BF4113

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Product: Caveolin 3 Recombinant Rabbit mAb
Catalog: BF4113
Description: Rabbit monoclonal antibody to Caveolin 3
Application: WB IHC
Reactivity: Human, Mouse, Rat
Mol.Wt.: 17 kDa(Observed); 17kD(Calculated).
Uniprot: P56539

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MSDS
Data Sheet
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Protocols
WB Handbook
IHC Protocol
IF/ICC Protocol

Product Info

Source:
Rabbit IgG
Application:
WB 1:1000-1:5000, IHC 1:500-1:2000
*The optimal dilutions should be determined by the end user. For optimal experimental results, antibody reuse is not recommended.
*Tips:

WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.

Reactivity:
Human, Mouse, Rat
Clonality:
Monoclonal [ReFirm23560]
Specificity:
Caveolin 3 Recombinant Rabbit mAb detects endogenous levels of Caveolin 3.
Conjugate:
Unconjugated.
Purification:
Affinity-chromatography.
Storage:
Rabbit IgG in Tris-Glycine (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at -20 °C. Stable for 12 months from date of receipt.
Alias:

Fold/Unfold

LQT9,MPDT,RMD2,VIP21,LGMD1C,VIP-21

Immunogens

Immunogen:

A synthetic peptide from human Caveolin 3

Uniprot:

P56539(CAV3_HUMAN) >>Visit HPA database.

Gene(ID):
CAV3(859)
Expression:
P56539 CAV3_HUMAN:

Expressed predominantly in muscle.

Description:
This gene encodes a caveolin family member,which functions as a component of the caveolae plasma membranes found in most cell types. Caveolin proteins are proposed to be scaffolding proteins for organizing and concentrating certain caveolin-interacting molecules. Mutations identified in this gene lead to interference with protein oligomerization or intra-cellular routing,disrupting caveolae formation and resulting in Limb-Girdle muscular dystrophy type-1C (LGMD-1C),hyperCKemia or rippling muscle disease (RMD). Alternative splicing has been identified for this locus,with inclusion or exclusion of a differentially spliced intron. In addition,transcripts utilize multiple polyA sites and contain two potential translation initiation sites.
Sequence:
MMAEEHTDLEAQIVKDIHCKEIDLVNRDPKNINEDIVKVDFEDVIAEPVGTYSFDGVWKVSYTTFTVSKYWCYRLLSTLLGVPLALLWGFLFACISFCHIWAVVPCIKSYLIEIQCISHIYSLCIRTFCNPLFAALGQVCSSIKVVLRKEV

Research Backgrounds

Function:

May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity. May also regulate voltage-gated potassium channels. Plays a role in the sarcolemma repair mechanism of both skeletal muscle and cardiomyocytes that permits rapid resealing of membranes disrupted by mechanical stress (By similarity). Mediates the recruitment of CAVIN2 and CAVIN3 proteins to the caveolae.

PTMs:

Sumoylation with SUMO3 by PIAS4 may reduce agonist-induced internalization and desensitization of adrenergic receptor ABRD2.

Subcellular Location:

Golgi apparatus membrane>Peripheral membrane protein. Cell membrane>Peripheral membrane protein. Membrane>Caveola>Peripheral membrane protein. Cell membrane>Sarcolemma.
Note: Potential hairpin-like structure in the membrane. Membrane protein of caveolae (By similarity).

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionSubcellular location
Tissue Specificity:

Expressed predominantly in muscle.

Family&Domains:

Belongs to the caveolin family.

Research Fields

· Cellular Processes > Transport and catabolism > Endocytosis.   (View pathway)

· Cellular Processes > Cellular community - eukaryotes > Focal adhesion.   (View pathway)

· Human Diseases > Infectious diseases: Bacterial > Bacterial invasion of epithelial cells.

· Human Diseases > Cancers: Overview > Proteoglycans in cancer.

Restrictive clause

 

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For Research Use Only.
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