APRIL/TNFSF13 Recombinant Rabbit mAb - #BF4555

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Product: APRIL/TNFSF13 Recombinant Rabbit mAb
Catalog: BF4555
Description: Rabbit monoclonal antibody to APRIL/TNFSF13
Application: WB
Reactivity: Human, Mouse, Rat
Mol.Wt.: 27 kDa(Observed); 27kD(Calculated).
Uniprot: O75888

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Product Info

Source:
Rabbit IgG
Application:
WB 1:1000-1:5000
*The optimal dilutions should be determined by the end user. For optimal experimental results, antibody reuse is not recommended.
*Tips:

WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.

Reactivity:
Human, Mouse, Rat
Clonality:
Monoclonal [ReFirm24005]
Specificity:
APRIL/TNFSF13 Recombinant Rabbit mAb detects endogenous levels of APRIL/TNFSF13.
Conjugate:
Unconjugated.
Purification:
Affinity-chromatography.
Storage:
Rabbit IgG in Tris-Glycine (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at -20 °C. Stable for 12 months from date of receipt.
Alias:

Fold/Unfold

A proliferation inducing ligand; A proliferation-inducing ligand; APRIL; CD256; TALL-2; TALL2; TNF related death ligand; TNF- and APOL-related leukocyte expressed ligand 2; TNF-related death ligand 1; TNF13_HUMAN; TNFSF13; TRDL-1; TRDL1; Tumor necrosis factor (ligand) superfamily, member 13; Tumor necrosis factor ligand superfamily member 13; Tumor necrosis factor like protein ZTNF2; Tumor necrosis factor related death ligand 1; UNQ383/PRO715; ZTNF2;

Immunogens

Immunogen:

A synthetic peptide from human APRIL

Uniprot:

O75888(TNF13_HUMAN) >>Visit HPA database.

Gene(ID):
TNFSF13(8741)
Expression:
O75888 TNF13_HUMAN:

Expressed at high levels in transformed cell lines, cancers of colon, thyroid, lymphoid tissues and specifically expressed in monocytes and macrophages.

Description:
The protein encoded by this gene is a member of the tumor necrosis factor (TNF) ligand family. This protein is a ligand for TNFRSF17,BCMA,a member of the TNF receptor family. This protein and its receptor are both found to be important for B cell development. In vitro experiments suggested that this protein may be able to induce apoptosis through its interaction with other TNF receptor family proteins such as TNFRSF6,FAS and TNFRSF14,HVEM. Alternative splicing results in multiple transcript variants. Some transcripts that skip the last exon of the upstream gene (TNFSF12) and continue into the second exon of this gene have been identified,such read-through transcripts are contained in GeneID 407977,TNFSF12-TNFSF13.
Sequence:
MPASSPFLLAPKGPPGNMGGPVREPALSVALWLSWGAALGAVACAMALLTQQTELQSLRREVSRLQGTGGPSQNGEGYPWQSLPEQSSDALEAWENGERSRKRRAVLTQKQKKQHSVLHLVPINATSKDDSDVTEVMWQPALRRGRGLQAQGYGVRIQDAGVYLLYSQVLFQDVTFTMGQVVSREGQGRQETLFRCIRSMPSHPDRAYNSCYSAGVFHLHQGDILSVIIPRARAKLNLSPHGTFLGFVKL

Research Backgrounds

Function:

Cytokine that binds to TNFRSF13B/TACI and to TNFRSF17/BCMA. Plays a role in the regulation of tumor cell growth. May be involved in monocyte/macrophage-mediated immunological processes.

PTMs:

The precursor is cleaved by furin.

Subcellular Location:

Secreted.

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionSubcellular location
Tissue Specificity:

Expressed at high levels in transformed cell lines, cancers of colon, thyroid, lymphoid tissues and specifically expressed in monocytes and macrophages.

Family&Domains:

Belongs to the tumor necrosis factor family.

Research Fields

· Environmental Information Processing > Signaling molecules and interaction > Cytokine-cytokine receptor interaction.   (View pathway)

· Human Diseases > Immune diseases > Rheumatoid arthritis.

· Organismal Systems > Immune system > Intestinal immune network for IgA production.   (View pathway)

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