Product: ATF6B Antibody
Catalog: DF3412
Description: Rabbit polyclonal antibody to ATF6B
Application: WB IHC IF/ICC
Reactivity: Human, Mouse, Rat, Monkey
Mol.Wt.: 76 KD; 77kD(Calculated).
Uniprot: Q99941
RRID: AB_2835794

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 100ul $280 In stock
 200ul $350 In stock

Lead Time: Same day delivery

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Product Info

WB 1:500-1:1000, IF/ICC 1:100-1:500, IHC 1:50-1:200
*The optimal dilutions should be determined by the end user.

WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.

ATF6B Antibody detects endogenous levels of total ATF6B.
Cite Format: Affinity Biosciences Cat# DF3412, RRID:AB_2835794.
The antiserum was purified by peptide affinity chromatography using SulfoLink™ Coupling Resin (Thermo Fisher Scientific).
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at -20 °C. Stable for 12 months from date of receipt.


Activating transcription factor 6 beta; ATF 6 beta; ATF6-beta; ATF6B; ATF6B_HUMAN; ATF6beta; cAMP response element binding protein related protein; cAMP response element-binding protein-related protein; cAMP responsive element binding protein like 1; cAMP-dependent transcription factor ATF-6 beta; cAMP-responsive element-binding protein-like 1; CREB L1; Creb related protein; CREB RP; Creb-rp; CREBL 1; CREBL1; Crebrp; Cyclic AMP dependent transcription factor ATF 6 beta; Cyclic AMP dependent transcription factor ATF6 beta; FLJ10066; G13; G13 protein; OTTHUMP00000029432; OTTHUMP00000029433; Processed cyclic AMP-dependent transcription factor ATF-6 beta; Protein G13;





PTMs - Q99941 As Substrate

Site PTM Type Enzyme
A2 Acetylation
S89 Phosphorylation
S93 Phosphorylation
S279 Phosphorylation
K305 Ubiquitination
S306 Phosphorylation
K324 Ubiquitination
S546 Phosphorylation
S564 Phosphorylation
S618 Phosphorylation
K668 Ubiquitination

Research Backgrounds


Transcriptional factor that acts in the unfolded protein response (UPR) pathway by activating UPR target genes induced during ER stress. Binds DNA on the 5'-CCAC[GA]-3' half of the ER stress response element (ERSE) (5'-CCAATN(9)CCAC[GA]-3') when NF-Y is bound to ERSE.



During unfolded protein response, a fragment of approximately 60 kDa containing the cytoplasmic transcription factor domain is released by proteolysis. The cleavage is probably performed sequentially by site-1 and site-2 proteases.

Subcellular Location:

Endoplasmic reticulum membrane>Single-pass type II membrane protein.

Note: Under ER stress the cleaved N-terminal cytoplasmic domain translocates into the nucleus.

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionSubcellular location
Tissue Specificity:


Subunit Structure:

Homodimer and heterodimer with ATF6-alpha. The dimer interacts with the nuclear transcription factor Y (NF-Y) trimer through direct binding to NF-Y subunit C (NF-YC).


The basic domain functions as a nuclear localization signal.

The basic leucine-zipper domain is sufficient for association with the NF-Y trimer and binding to ERSE.

Belongs to the bZIP family. ATF subfamily.

Research Fields

· Environmental Information Processing > Signal transduction > cGMP-PKG signaling pathway.   (View pathway)

· Environmental Information Processing > Signal transduction > PI3K-Akt signaling pathway.   (View pathway)

· Environmental Information Processing > Signal transduction > TNF signaling pathway.   (View pathway)

· Genetic Information Processing > Folding, sorting and degradation > Protein processing in endoplasmic reticulum.   (View pathway)

· Human Diseases > Substance dependence > Cocaine addiction.

· Human Diseases > Substance dependence > Amphetamine addiction.

· Human Diseases > Substance dependence > Alcoholism.

· Human Diseases > Infectious diseases: Viral > Hepatitis B.

· Human Diseases > Cancers: Overview > Viral carcinogenesis.

· Organismal Systems > Aging > Longevity regulating pathway.   (View pathway)

· Organismal Systems > Circulatory system > Adrenergic signaling in cardiomyocytes.   (View pathway)

· Organismal Systems > Nervous system > Dopaminergic synapse.

· Organismal Systems > Endocrine system > Insulin secretion.   (View pathway)

· Organismal Systems > Endocrine system > Estrogen signaling pathway.   (View pathway)

· Organismal Systems > Endocrine system > Thyroid hormone synthesis.

· Organismal Systems > Endocrine system > Aldosterone synthesis and secretion.

· Organismal Systems > Endocrine system > Relaxin signaling pathway.

Restrictive clause


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For Research Use Only.
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